Research Interests
Obesity, hypertension and Type II diabetes are major health problems for Australia and are likely to increase in the 21st century. One of the common features of these conditions is insulin resistance in skeletal muscle. Dr Rattigan’s research has focussed on the factors that regulate glucose metabolism in skeletal muscle and have led to the important finding that blood flow regulation within muscle is critical to the normal responses to insulin. Impairment of normal blood flow distribution within muscle can lead to insulin resistance and it is his current hypothesis that such defects are the early events associated with obesity and hypertension that contribute to Type II diabetes.
Research Areas:
Selected Publications:- Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S., 2003, 'Inhibiting NOS blocks microvascular recruitment and blunts muscle uptake in response to insulin.', Am. J. Physiol. Endocrinol Metab., 285 (1):, pgs. E123-9
- Rattigan S, BarrettEJ, Clark MG, 2003, 'Insulin-mediated capillary recruitment in skeletal muscle: is this a mediator of insulin action on glucose metabolism?', Curr. Diab. Rep., 3(3):, pgs. 195-200
- Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, Clerk LH, Rattigan S, 2003, 'Blood flow and muscle metabolism: a focus on insulin action.', Am. J. Physiol. Endocrinol. Metab., 284(2):, pgs. E241-58
- Vincent MA, Dawson D, Clark AD, Lindner JR, Rattigan S, Clark MG, Barrett EJ, 2002, 'Skeletal muscle microvascular recruitment by physiological hyperisulinemia precedes increases in total blood flow.', Diabetes., 51(1), pgs. 42-8
- Rattigan S, Wallis MG, Youd JM, Clark MG, 2001, 'Exercise training improves insulin-mediated capillary recruitment in association with glucose uptake in rat hindlimb.', Diabetes., 50(12), pgs. 2659-65
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