Research Interests
Dr Holloway is a molecular biologist interested in the regulation of gene expression. Her research is primarily focused on understanding how genes are switched on and off in response to specific cellular signals. This research employs a range of molecular and cell biology based techniques to investigate the molecular mechanisms involved in switching on gene expression in cells of the immune system. A current project is investigating the cellular signals and factors involved in switching on expression of the cytokine GM-CSF in T cells. Disruption of normal gene expression programs is a contributing factor in a range of immune diseases including certain leukemias, asthma and arthritis.
Research Areas:Teaching
Dr Holloway is involved in teaching biochemistry and molecular biology to second and third year students
UnitsSelected Publications:- Holloway, AF, Stennard, FA, Dziegielewska, KM, Weller, WL, West, AK, 1997, 'Localisation and expression of metallothionein immunoreactivity in the developing sheep brain', International Journal of Developmental Neuroscience, 15, pgs. 195-203
- Holloway, AF, Stennard, FA, West, AK, 1997, 'Human metallothionein gene MT1l mRNA is present in several tissues but is unlikely to produce a metallothionein protein', FEBS letters, 404, pgs. 41-44
- Holloway, AF, Rao, S, Shannon, MF, 2002, 'Regulation of cytokine gene transcription in the immune system', Molecular Immunology, 38, pgs. 567-580
- Holloway, AF, Occhiodoro, F, Mittler, G, Meisterernst, M, Shannon, MF, 2000, 'Functional interaction between the HIV transactivator, Tat, and the transcriptional coactivator PC4 in T cells', Journal of Biological Chemistry, 275, pgs. 21668-21677
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