Research Interests
Role of neurotrophic factors (NTFs) and receptors in the nervous system, particularly in the hypothalamus and their role in the regulation of energy balance (body weight).
Potential of NTFs as treatments for neurodegenerative diseases, particularly Parkinson's disease.
Research Areas:Teaching
Coordinate gross anatomy teaching (lectures, practicals, tutorials, etc) to first, second, and third year medical students.
Participate in neuroscience teaching, including lectures and practicals.
Tutorials in human biology and biochemistry.
UnitsSelected Publications:- Choi-Lundberg, D.L., Lin, Q., Schallert, T., Crippens, D., Davidson, B.L., Chang, Y.-N, Chiang, Y.L., Qian, J., Bardwaj, L., Bohn, M.C., 1998, 'Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor (GDNF)', Experimental Neurology, 154, pgs. 261-275
- Bohn, M.C., Choi-Lundberg, D.L., Davidson, B.L., Leranth, C., Kozlowski, D.A., Smith, J.C., O'Banion, M.K., Redmond, D.E., Jr., 1999, 'Adenoviral-mediated transgene expression in non-human primate brain', Human Gene Therapy, 10, pgs. 1175-1184
- Gerlai, R., McNamara, A., Choi-Lundberg, D.L., Armanini, M., Ross, J., Powell-Braxton, L., Phillips, H.S., 2001, 'Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation', European Journal of Neuroscience, 14, pgs. 1153-1163
- Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P.E., Shinsky, N., Verdugo, J.M.G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A., 2000, 'Mice lacking _alpha-synuclein display functional deficts in the nigrostriatal dopamine system', Neuron, 25, pgs. 239-252
- Choi-Lundberg, D.L., Lin, Q., Chang, Y.-N., Chiang, Y.L., Hay, C.M., Mohajeri, H., Davidson, B.L., Bohn, M.C., 1997, 'Dopaminergic neurons protected from degeneration by GDNF gene therapy', Science, 275, pgs. 838-841
Current and Supervised Project/s:
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