Haemostasis and Thrombosis
Research Overview
Thrombosis (“blood clots”) and associated manifestations such as atherosclerosis are leading causes of morbidity and mortality in developed countries and are complications that develop in a wide range of diseases, including cancer, chronic kidney disease, diabetes, stroke and autoimmune diseases such as systemic lupus erythromatosus (SLE) and the anti-phospholipid syndrome (aPS). With an aging population both in Tasmania and Australia, the costs associated with the diagnosis and treatment of thrombosis are forecast to provide a significant financial burden on the healthcare system. My research aims to investigate aspects of haemostasis e.g. blood coagulation and platelet function, to identify abnormalities that lead to thrombosis.
Current Collaborators
| Dr Kiran Ahuja |
School of Human Life Sciences |
| Professor Madeleine Ball |
School of Human Life Sciences |
| Mr Paul Ellery |
Curtin University of Technology, WA |
| A/Prof Dominic Geraghty |
School of Human Life Sciences |
| Dr Alhossain Khalafallah |
Launceston General Hospital, TAS |
| Dr Lisa Lincz |
University of Newcastle, NSW |
| Dr Michael Seldon |
Hunter Area Pathology Service, NSW |
| Dr Cecilia Shing |
School of Human Life Sciences |
Methods
The laboratory is well resourced to conduct a variety of techniques, including affinity chromatography, amidolytic activity assays, thrombin generation assays, cell culture, full blood counts, platelet aggregometry, routine coagulation tests, SDS-PAGE, Western Blotting and ELISA.
Funding
Research is currently supported by University of Tasmania and Clifford Craig Medical Research Trust.
Link to Publications and Current Projects (via WARP): (http://rmdb.research.utas.edu.au/public/rmdb?indiv_detail_warp_trans+20036)
Other Links
- Australian Institute of Medical Scientists (http://www.aims.org.au/)
- Australasian Society of Thrombosis and Haemostasis (http://www.asth.org.au/)
- Haematology Society of Australia and New Zealand (http://www.hsanz.org.au/)
- International Society on Thrombosis and Haemostasis (http://www.med.unc.edu/isth/)
- Research at the University of Tasmania (http://www.research.utas.edu.au/)
- School of Human Life Sciences (http://www.hls.utas.edu.au/)
Past and current research students and associated projects.
2008. Annalise Harvey: "Interaction of Antiphospholipid Antibodies with the Tissue Factor Pathway of Blood Coagulation".
Contact
For further information on current and/or future projects, please contact Dr Murray Adams (email: Murray.Adams@utas.edu.au, or phone: +61 3 6324 5483).
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